Journal of Applied Sciences and Clinical Practice

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Background: Polycystic ovarian syndrome (PCOS) is the most common endocrinopathy affecting women of reproductive age with prevalence of about 4%–20%. Aim: This study aims to evaluate serum adiponectin and fertility hormones in women with PCOS, and the subsequent effect of omega-3 supplementation. Subjects and Methods: One hundred and fifty women aged 18–40 years were assigned into groups A and B comprising women with PCOS and control, respectively. Group A was further subdivided into groups 1 and 2 receiving omega-3 and placebo daily for 12 weeks, respectively. Blood samples were collected before and after 12 weeks of supplementation for analysis of adiponectin, follicle stimulating hormone (FSH), luteinizing hormone (LH), testosterone, prolactin, estradiol, progesterone, and sex hormone binding globulin (SHBG). Statistical Package for Social Sciences (SPSS) version 23.0 was used for data analysis, and the level of statistical significance was set at P < 0.05. Results: Serum adiponectin, progesterone, and SHBG were significantly lower while FSH, LH, testosterone, prolactin, and estradiol were significantly higher in women with PCOS when compared with the control (P < 0.05). Adiponectin and progesterone levels increased significantly while FSH, LH, testosterone, prolactin, and estradiol levels decreased significantly after 12 weeks of omega-3 supplementation when compared with the levels at baseline as well as when compared with those on placebo (P < 0.05). Statistical Package for Social Sciences (SPSS) version 23.0 was used for data analysis. Conclusion: Omega-3 may be beneficial in improving certain hormonal alterations in women with PCOS. Omega-3 supplements may therefore be used as part of the regimen in the management of patients with PCOS.

Background: During the pandemic situation of coronavirus disease 2019 (COVID-19), nursing professionals being frontline warriors, need to fight with the disease of unknown dimensions, put efforts to manage misunderstandings among the general population, face health risks for self and family members, and experience challenges to improve professional skills. All these demanding situations act as stressors and can enhance stress among them. Materials and Methods: The cross-sectional survey was conducted using web-based questionnaire. Information was collected from 200 nursing personnel's working in the COVID intensive care unit of selected tertiary care hospitals. The questionnaire used for data collection comprised two sections: First section focused on sociodemographic profile of subjects and the second section included the Psychometric Evaluation of Healthcare Workers' Stress Related to Caring for Patients with a Highly Infectious Disease scale. Results: The result revealed that maximum 57% of the subjects had moderate COVID-19 related stress. The highest stress scores were identified for items: (i) Ethical dilemma as humanitarian visitation is banned due to quarantine measures; (ii) Restrictions on eating and drinking at work; (iii) Feeling overburdened with work; (iv) Limited number of staff allowed access to the isolation room and thus inability to obtain adequate assistance; and v) Feeling breathless with an N95 or P100 face mask. Discomfort caused by protective equipment was the top-most stressor identified by the participants, followed by fear of social isolation and the burden of caring for patients. Conclusions: The hospital administration and nurse managers should continuously monitor the psychological health of Nursing Professionals in this COVID-19 era and plan timely interventions to promote their health.

Cough is the most common respiratory symptoms with infective and noninfective etiological factors involving upper and lower airways. Chronic refractory cough (CRC) has limited etiology and associated symptoms play a crucial role in differentiating it from underlying benign to malignant pathology. Computed tomography (CT) thorax has a vital role in evaluating “CRC with dyspnea” and findings like interlobular septal thickening with nodules will be good answer to etiology. “Beaded interlobular septum with nodules, and enhancing cannonball like nodule” clinching causative factor may be malignant process outside the thoracic cavity. In this case report, a 52-year male presented with CRC and documented lymphangitis with nodule on high-resolution computed tomography thorax and CT abdomen documented right renal mass, ultrasound-guided right renal biopsy documented renal papillary carcinoma. Renal metastasis which predominantly involves both lymphatic and hematogenous route, and propensity of these metastases are hyper-vascular type and presenting with lymphatic interlobular septal dissemination with lymphatic edema resulting in refractory chronic cough with dyspnea which is refractory to steroids and bronchodilators.

Purpose: The purpose of this study is aimed to assess the impact of simulation in addition to conventional training on knowledge and self-efficacy of the nursing students in handling common pediatric conditions covered under integrated management of neonatal and childhood illnesses. Methods: In a pretest–posttest control group design, 61 nursing students were randomly assigned to an experimental and control groups. The intervention for the control group consisted of 30 h conventional teaching on the management of common pediatric conditions, while the experimental group received additional simulation training of 5 h duration along with conventional teaching. Results: Both experimental (n = 30) and control groups (n = 30) were similar in demographic characteristics and baseline academic qualifications. There was a significant increase in knowledge and self-efficacy scores in both the groups (P < 0.001) with postintervention scores being significantly higher for knowledge (17.8 [2.1] vs. 15.5 [1.9], P < 0.001) and self-efficacy (34.4 [2.5] vs. 32.3 [2.9], P = 0.004) in the experimental group. Conclusion: An add-on simulation-based training to conventional teaching led to better knowledge and self-efficacy level in handling common pediatric conditions.

Online since 18^th September 2020